Two sample MR report
KCNMA1_Dendritic Cell (DC) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0962503 | 0.2669399 | 0.7796918 |
| Weighted median | 3 | -0.0404543 | 0.0216501 | 0.0616857 |
| Inverse variance weighted | 3 | -0.0475584 | 0.0179216 | 0.0079619 |
| Simple mode | 3 | -0.0399823 | 0.0246826 | 0.2466946 |
| Weighted mode | 3 | -0.0400484 | 0.0258951 | 0.2620217 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1434610 | 1 | 0.7048643 |
| Inverse variance weighted | 0.4350056 | 2 | 0.8045254 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0953581 | 0.1766059 | 0.6848137 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.79e-05 | 0 | TRUE | 0.5135052 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
